How to use Femara. Read the Patient Information Leaflet provided by your pharmacist before you start using letrozole and each time you get a refill. I took tamoxifen for 5 yrs and femara for 5 yrs. and had minimal side effects while on the meds. since Ive been off, it seems as though my minor side effects have gotten worse. According to Randy S. Morris – founder and Medical Director of IVF1 – Femara has an increased efficacy and lower risk of producing multiple pregnancies compared to Clomid. Femara is ideal for use only if you want to get pregnant despite having PCOS. You should consult your doctor and follow his advice instead of choosing to pop the medicine on your own accord. You should consult your doctor and follow his advice instead of choosing to pop the medicine on your own accord. How to use Letrozole. Read the Patient Information Leaflet provided by your pharmacist before you start using letrozole and each time you get a refill. Femara (generic name is letrozole) is an oral drug which can be an effective fertility treatment for women with ovulation problems, or for those with unexplained infertility. This medication is in a class of drug called aromatase inhibitors. Femara official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Femara is an anti-estrogen drug typically used for treating postmenopausal women with breast cancer. Side effects of Femara and Clomid that are similar include nausea, vomiting, headache, and muscle aches or pains. Summary. Cigarette smoking is found among people who take Femara, especially for people who are female, 40-49 old also take medication Neulasta, and have Metastases to bone. Letrozole (Femara) In many fertility centers, clomiphene citrate (Clomid, Serophene) has been the drug of first choice for either ovulation induction or superovulation for many years. In general, it has been a relatively effective medication.